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Equine Cushing’s and Insulin Resistance Group Inc.

IR Calculator & Leptin

IR Calculator
Enter blood results in the boxes below, then click the "calculate" button for results.
Insulin Value
Insulin Unit of Measure
Insulin Convert
Glucose Value
Glucose Unit of Measure
Glucose Convert

IR Calculations
G/I Ratio
RISQI Calculaton
MIRG Calculation
G/I Interpretation
RISQI Interpretation
MIRG Interpretation

Leptin Calculations
Leptin value is entered separately.
Leptin Value
Leptin Interpretation

NOTE: Some labs report insulin as mU/L which is equivalent to uIU/mL.

IR can be diagnosed from insulin (RISQI) and leptin alone, but it's helpful to know glucose to make sure the horse is not in the diabetic range.

MIRG > 5.6 indicates IR even when the G/I ratio does not.

Leptin is more sensitive than insulin and can still be abnormal even if insulin is not.

Risk of IR increases at the higher leptin values although sudden changes in nutrient requirements, such as foaling or starting a regular training program, can result in leptin in the 5 to 6 range.


  • Treiber KH, Kronfeld DS, Hess TM, Boston RC, Harris PA. Use of proxies and reference quintiles obtained from minimal model analysis for determination of insulin sensitivity and pancreatic beta-cell responsiveness in horses AJVR, Vol 66, No. 12, December 2005.
  • Cartmill, JA. Influences of body condition, gender, insulin sensitivity, feeding and dexamethasone., PhD dissertation 2004.